with Vitamin C and MSM

Walter Last

Health authorities generally set such low limits for the recommended daily allowance (RDA) of vitamins and minerals that obvious deficiencies in most individuals are avoided but so that these nutrients do not become a threat to the pharmaceutical industry by preventing and curing diseases. In this article I like to show what can be done with higher amounts of vitamin C as pioneered by doctors Linus Pauling, Ewan Cameron, Abram Hoffer and others. The results are even better when combined with MSM (methylsulfonylmethane or dimethylsulfone) and DMSO (dimethylsulfoxide).

There are hundreds of vitamin C articles with positive results published in the peer-reviewed Journal of Orthomolecular Medicine ( which specializes in vitamin research. In an act of obvious bias the MEDLINE database lists all articles by medical research journals, including Time magazine and Readers' Digest, but not the Journal of Orthomolecular Medicine. Because all these highly positive studies are not indexed by Medline, proponents of drug medicine can claim that there are no studies showing that vitamin C is useful and safe in the treatment of diseases.

30 years ago Linus Pauling and Ewan Cameron showed that high doses of vitamin C are beneficial in cancer treatment. This has been ‘disproved’ by the orthodoxy ever since. But now a study by conventional Johns Hopkins scientists has shown that they were right after all (1). There are, of course, countless studies and reports on the value of vitamin C for preventing and treating infections, but only if enough of it is being used.

In critical conditions alternative medical practitioners like to give weekly infusions of 30 to 120 grams of sodium ascorbate. While these can definitely be helpful, I now believe it is more effective for most conditions to gradually increase the orally taken amount close to bowel tolerance level. When diarrhoea or "loose bowels" start to develop then just cut back by 10 to 20% to a more comfortable level. In the following I want to focus mainly on lesser known aspects of using high doses of vitamin C, MSM and DMSO.

More Energy

There are many stories and anecdotal reports about people feeling more energetic by supplementing with vitamin C, MSM, DMSO and niacinamide (vitamin B3), either individually or taken all together. I can confirm these from my own experience. Here just a few examples from the Internet (2).

Dr Stanley Jacob presented 3 case histories where five, ten and thirty grams per day of MSM reduced or eliminated fatigue and pain in fibromyalgia and chronic fatigue. A competitive athlete mixed equal amounts of MSM and Vitamin C powder and drank it in the morning. It gave him an extreme rush of energy, considerably more than either one did alone. Dr Abram Hoffer helped thousands of patients with cancer and schizophrenia with high doses of vitamin C and vitamin B3.

Here a paraphrased story: I spread a liberal amount of DMSO on my abdomen. A few hours later I played tennis and I felt a very large increase in energy and agility. I have repeated this a number of times since with the same result.

Another paraphrased example about Alzheimer's disease/senile confusion: Gave mom some liquid DMSO in juice and within an hour a new woman! She could have conversation, laugh, be alert. When the DMSO wore off back to the fatigued, yawning and disorientated person. So, I gave some more DMSO, a whole teaspoonful, and within an hour she came alive again, hold conversation, have energy.

Also niacinamide improved memory and energy in Alzheimer's disease (3). This is no real surprise because it works also in many other conditions, such as improving or normalising schizophrenia, senile conditions, arthritis, hyperactivity or behavioural and learning difficulties of children, cancer, dermatitis, juvenile diabetes, fatigue and lack of energy (4). The reason why a single vitamin can help with all of these problems is its key role as a coenzyme in oxidative cellular energy production. Some other important nutrients for the oxidative metabolism are copper and the vitamins B2 and B6. 

In the following I will try to explain how we can understand this energy boost as a result of increased oxygen supply to anaerobic cells.

Alternative Oxygen Supply

Our main oxygen distribution is with the haemoglobin in red blood cells. A problem with it is that oxygen is released into the tissues only in response to the presence of carbon dioxide as generated with the aerobic energy metabolism through muscle or brain activity.

People with a high amount of Candida, fungi and other myco-microbes have an anaerobic metabolism in parts of the brain and in many muscles and organs. Also cancer cells have an anaerobic metabolism and can become normal with increased oxygen supply so that tumours may just melt away (5). Anaerobic cells do not produce carbon dioxide, and therefore do not get sufficient oxygen from the normal blood circulation. This makes it understandable why it is highly beneficial with all anaerobic and low-energy conditions to use additional oxygen supply methods that do not require carbon dioxide to release oxygen.

Best suited for supplementation are vitamin C and MSM. These form reduction-oxidation or redox pairs. One such pair is vitamin C (ascorbic acid or ascorbate) as the reduced form and dehydroascorbic acid or DHA as the oxidized form. Another one is DMSO as the reduced form and MSM as the oxidized one (6).

The principle of action is as follows: In an oxygen deficient environment such as a cell with anaerobic metabolism a redox pair changes from their oxidized state to their reduced form by giving off one atom of highly reactive oxygen. When vitamin C or DMSO return to the circulation and flow with the blood through the lungs they are again being converted to their oxidized forms. In this way the redox cycle can repeat several times until the chemicals are gradually being excreted through the kidneys, and an oxidative energy metabolism can be restored in anaerobic tissue where this is not possible with the oxygen in red blood cells. 

DHA is the form in which vitamin C gets into the brain and most other cells. Vitamin C cannot enter directly in its reduced form, it only gets inside cells as DHA. Inside the cell it is then reduced by liberating oxygen. With the normal intake levels of vitamin C and MSM the released amount of oxygen is so low that it does not make a difference, and especially not in cells that produce carbon dioxide and get their oxygen from haemoglobin. But it can make a world of difference in anaerobic tissue, and with high intakes of vitamin C and MSM. The oxygen released in this way is initially highly reactive and kills the microbes inside the cells that caused this blockage, and then re-starts the blocked oxidative energy metabolism. This is how vitamin C protects us against cancer and infections if we use enough of it.

I do not regard hydrogen peroxide and ozone as suitable oxygen delivery systems to restore the cellular oxygen metabolism. While hydrogen peroxide can be very beneficial to destroy or control fungal-type microbes in the stomach and small intestines, it is not normally suitable for delivering oxygen to anaerobic tissues deeper within the body as it is too reactive, and in the high amounts needed would cause too much damage to antioxidant systems. It has been used with good results, just like ozone, to destroy blood-born microbes by intravenous infusions. But even blood can probably be cleaned just as well or better with frequent oral doses of sodium ascorbate and MSM than with occasional intravenous courses of hydrogen peroxide or ozone.

I regard this alternative oxygen supply as being very effective in all conditions of low energy, mental-emotional conditions, cancer, autoimmune diseases, liver diseases, fibromyalgia, chronic fatigue, and all other fungal or Candia-related diseases as well as chronic inflammations and infections.

Cleaning Blood Vessels

Blood vessel congestion is the main underlying cause of many serious diseases, such as cardiovascular disease (CVD) leading to heart attacks and strokes, and peripheral vascular disease (PVD) leading to varicose veins, deep vein thrombosis, leg ulcers potentially causing leg amputation in diabetes, and poor blood supply to the brain. Many common conditions such as arthritis, degenerative eye changes (e.g. cataracts, macular degeneration), migraines, and multiple sclerosis are aggravated by it. I noticed symptoms attributed to multiple sclerosis or nerve degeneration disappearing with improved blood circulation.

The position of the medical orthodoxy is that atherosclerosis, the clogging up of blood vessels with cholesterol, is caused by high levels of low-density lipoproteins, transporting mainly cholesterol from the liver to other parts of the body. The main problem with this theory is that many individuals with persistently high LDL levels never have a heart attack, and many individuals with low or normal LDL levels do have heart attacks.

In 1991 and 1992 doctors Matthias Rath and Linus Pauling wrote important articles linking the development and cure of CVD and PVD to vitamin C deficiency (7, 8). They showed that it is actually a variant of LDL, namely lipoprotein(a) or Lp(a), and not LDL that is accumulating in the blood vessel wall causing atherosclerosis. Lp(a) is formed in increasing amounts in the liver in response to low ascorbate concentrations. Animals, except for primates and guinea pigs produce their own vitamin C at a comparable daily rate of several grams in humans. It therefore comes as no surprise that CVD is essentially unknown in animals, and Lp(a) is mainly found in species that have lost the ability to produce their own ascorbate.

Ascorbate deficiency results in degenerative changes of the blood vessel wall, potentially leading to life-threatening bleeding disorders. To avoid such unwanted consequences, low ascorbate levels at the same time increase the plasma concentration of factors that constrict blood vessels and increase blood clotting, including Lp(a) and fibrinogen. Accordingly, Lp(a) is deliberately accumulated in blood vessels damaged by vitamin C deficiency to strengthen the wall and prevent it from bleeding or bursting. An unwanted side effect of this defensive action is the clogging up of blood vessels like old water pipes, and the formation of blood clots, especially micro-clots blocking the blood flow in capillaries. With this vitamin C deficiency appears to be the main cause of acquired as well as inherited bleeding and blood clotting disorders.

Another side effect of vitamin C deficiency is high or low blood pressure. Hypertension is mainly associated with CVD and caused when the congestion of arteries and the blood vessel constricting effects dominate. Hypotension is mainly due to weakness and loss of elasticity in the veins, leading to PVD. In PVD triglyceride-rich lipoproteins accumulate in the plasma as very low-density lipoproteins (VLDL). These are easily oxidised by chlorinated water, smoking, polluted air, and other factors that deplete vitamin C and then form brownish coloured residues in affected tissues. Elevated glucose levels as in diabetes inhibit the cellular uptake of vitamin C, leading to greater degeneration of the blood circulation.

The authors and others have shown that prolonged high supplementation with ascorbate does not only protect against the development of CVD and PVD, but also gradually clears congested blood vessels and strengthens blood vessel walls. They also wrote:" The therapeutic significance of our discovery is not limited to CVD; Lp(a) and ascorbate are involved in cancer, inflammatory disease, and other diseases, including the process of aging" and "We are convinced that before long ascorbate will become the treatment of first choice for cardiovascular disease." Not unexpectedly this last statement is the only one in this article which has turned out to be totally wrong. Why would drug companies give up the highly profitable statins and face bankruptcy with vitamin C instead? Even if individual doctors were inclined to use vitamin C, the drug companies control the system. As I will point out below the drug companies are moving in the opposite direction by restricting the availability of vitamin C.


Individuals with iron overload problems, mainly the elderly and those with haemochromatosis (HC) may be reluctant to use vitamin C because of medical advice that it may increase iron absorption. However, from a biochemical perspective, iron overload is a problem of the redox balance with too much iron in the oxidised ferro-form accumulating in the liver. I have shown that this can easily be cured or rectified with a sufficiently high intake of vitamin C (10 grams of spaced-out sodium ascorbate/day) to normalise the overall redox potential of the body (9, 10).

I had several HC patients whose iron levels normalised within weeks with a high sodium ascorbate intake. The success rate was 100%, while with the low vitamin C intake suggested by conventional medicine it is 0%. My first patient with hereditary HC was treated conventionally for several years with frequent blood-letting, and was close to death without bringing the iron values into the normal range. But this happened within 20 days after starting ascorbate supplementation. He was anaemic with very low haemoglobin values, and additional Meniere's disease, also all of these normalised rapidly with the start of ascorbate therapy. Interestingly, when he reduced his ascorbate to 5 grams and also started eating meat his iron level moved up again and only normalised when increasing vitamin C to 10 grams.

In medicine HC is regarded as an iron overload disease because high amounts of oxidised iron in the form of ferritin (an iron-3 binding protein complex) are stored in the liver and cause oxidative problems also in other parts of the body. I prefer instead to regard it as an iron deficiency disease. The body is deficient in usable iron, that is why it sends out a message to absorb more of it.

Vitamin C not only improves the absorption of iron, it is also required to move iron in and out of ferritin tissue stores. Without adequate antioxidants, ferric iron stores may build up because iron cannot be liberated from tissue ferritin and transferred onto plasma transferrin, the main protein in the blood that binds to iron and transports it throughout the body. This step requires vitamin C for a temporary reduction of 3-valence ferric to 2-valence ferrous iron.

A main problem is the recycling of iron from the continual breakdown of haemoglobin in the spleen. About 25 mg of iron are recycled daily in this way, but this requires a reduction-oxidation step to transfer ferritin iron in the tissue onto plasma transferrin. With vitamin C deficiency there would be only a partial recycling. Most of the iron stores build up in the liver where the decomposed haemoglobin arrives through the portal vein after its liberation from old erythrocytes in the spleen.

This causes a very high oxidation potential in the liver, leading to various liver diseases and elevated liver enzymes. However, very high ferric iron stores in the liver would also make this organ more antioxidant deficient than other tissue. The highest vitamin C activity would be in the intestinal mucosa as these have first call on the antioxidants absorbed from food. Therefore, transferrin will preferentially pick up iron from the intestinal mucosa and avoid the liver stores as too difficult to convert.

Iron overload is not just a problem of our genes. It is a general problem as we get older but happens more rapidly in males and with liver diseases. Therefore it is probably a condition of most elderly individuals. This causes generalised vitamin C deficiency being expressed as a great variety of old-age symptoms. Two very common ones are connective tissue weakness and loss of hair colour.

Connective Tissue

Connective tissue holds the different parts of our body together. Examples of connective tissue are tendon, ligament, skin, cornea, cartilage, bone and blood vessels. Skin cells grow on a scaffolding of connective tissue, while bone consist of minerals within a matrix of connective tissue. The main component of connective tissue is collagen. It is structured as three protein strands arranged as a triple helix, and is the most abundant protein in the body.

Ascorbate is essential in forming different components of collagen and to assemble everything into the triple helix. Severe vitamin C deficiency causes scurvy in which collagen becomes defective and prevents the formation of strong connective tissue. Gums deteriorate and bleed with loss of teeth; skin discolours and breaks down, and wounds do not heal just as with diabetes. Another scurvy-like effect of vitamin C deficiency is haemorrhagic bleeding in the brain of children after vaccinations for which some parents were put in jail accused of causing "shaken baby syndrome".

Along with soft keratin, collagen makes the skin strong and elastic, its degradation leads to wrinkles, loose and ageing skin. Even more important for health is the effect on the blood vessels. Deficiency causes them to lose their elasticity, rigid and calcified arteries drive up the blood pressure and they can more easily break. This is especially a problem with aneurisms - ballooning enlargements of arteries with thin walls that can easily rupture (Albert Einstein died of a ruptured abdominal aneurism). In the veins vitamin C deficiency causes distension and slack walls so that the valves no longer close properly. The blood stagnates in the lower legs and pools to form varicose veins.

Now we can also understand sagging breasts and enlarged prostates as chronic vitamin C deficiencies rather than just advancing age. The prostate story is more complicated and goes like this: testosterone is partially converted in the testes and prostate into the much stronger dihydrotestosterone or DHT. It is then supposed to go with the blood circulation into the rest of the body. But with chronic ascorbate deficiency the blood keeps stagnating and pooling in or near the prostate leading to very high DHT levels that now stimulate prostate growth. The solution is improving the elasticity of connective tissue.

High DHT levels in the scalp are the main cause of male-pattern baldness. It appears that prostate enlargement is the result of DHT combined with a weak venous system (PVD) while male-pattern baldness is due to DHT in a congested arterial system or CVD. Both may, of course, be present simultaneously.

All of these problems - ageing skin, rigid arteries, aneurisms, varicose veins, sagging breasts, enlarging prostates and male-pattern baldness are signs of chronic vitamin C deficiency, commonly in combination with copper deficiency. Copper is also essential in forming connective tissue. Furthermore, plenty of sulphur is required either from sulphur-rich vegetables or MSM or both.

In addition to a high oral intake of sodium ascorbate it is beneficial to rub it onto the skin, good after a bath or shower. You may just pour some of the powder into your wet hands and rub it on the wet skin. Alternatively dissolve a teaspoon of sodium ascorbate in an egg cup of warm water and rub it all over the body. Let it dry on the skin without rubbing off with a towel. For quicker drying this may be done in the sun or in front of a heater, but the longer it stays wet the better it penetrates. Alternatively skin penetration may be improved by dissolving the ascorbate in aloe vera gel or 50% DMSO. Plenty of oral and topical vitamin C also prevents and may remove skin cancers. Melanoma also have disappeared after frequently rubbing with DMSO.

Hair Colour

Hair is coloured by the production of melanin in the hair bulbs. There are two kinds of melanin, eumelanin which colours the hair brown to black, and pheomelanin that makes it yellow-blond to red. Different combinations of these two kinds of melanin determine then the exact colour and shade of the hair.

White hair results when insufficient nutrients are supplied to the scalp to maintain normal melanin production in hair cells called melanocytes or when these are damaged by microbes, oxidation or heavy metals, especially mercury. Several nutrients are responsible to convert the amino acid tyrosine into melanin. The most common deficiency is with copper.

A convincing demonstration in regard to copper has been conducted with black sheep. When their feed was alternated several times containing high and low amounts of copper, they developed alternating black and white coloured bands in their wool; also the curliness was reduced when copper was low (11). 

Grey/gray hair contains much less copper than naturally coloured hair. It is not clear if high copper hair levels due to high intake of inorganic copper can be used for melanin production but I assume that it cannot be used. To restore hair colour I regard it as most useful to rub diluted copper salicylate solution directly into the scalp but additional oral intake may be helpful (12, 13).

Para-amino benzoic acid or PABA, which is related to the B group of vitamins and has a similar ring structure to tyrosine, helps to produce eumelanin and darkens the hair. Generally PABA has been effective in 10-25% of cases to darken grey or white hair; after stopping application the colour tends to fade again after several weeks. In clinical trials amounts from 400 mg up to 15 g of oral PABA have been used daily. PABA, used orally or topically, is also a natural sunscreen.

PABA itself is not water-soluble but may be dissolved in DMSO or by adding about one-third of bicarbonate to PABA suspended in water. Use about half a level teaspoon of PABA. After some fizzing the water will clear and the solution may now be rubbed into the scalp. Additional PABA may be taken internally with meals, but I regard the direct application as more effective. If available you may buy directly the water-soluble potassium or sodium salts of PABA.

Other nutrients required to maintain or restore natural hair colour are the B vitamins pantothenic acid, folic acid (in green leaves) and biotin (highest in egg yolk), and the quasi B vitamin inositol. Inositol stabilises cell membranes. This protects the hair bulbs and helps to keep the hair moist and so darkens its colour; severe deficiency may cause baldness. Zinc may be required in addition as well as iodine and sufficient calcium and magnesium. Overacidity causes mineral deficiency and premature greying of the hair.   

Another cause of fading hair colour is chronic stress. This may be due to emotional stress or to nutritional deficiency, or to chronic infections, most commonly related to Candida. In the normal metabolism free radicals and hydrogen peroxide are being formed. These need to be detoxified otherwise the melanin-producing enzymes are being damaged. Oral as well as topical treatment with fungicides and high amounts of vitamin C are most important to avoid this problem (14).

From this it also follows that regularly applying oxidants to the scalp as in the form of chlorinated water will lead to premature greying, and also seems to contribute to male-pattern baldness. Also drinking chlorinated water or cooking in it, or frying, all increase the ingestion of oxidized products and contribute to early greying. Hair colouring damages the hair, and it may then take longer for a natural colour to reappear. It is not clear if and to what degree completely white hair can regain some natural colouring; this may depend very much on additional measures to improve overall vitality and blood circulation to the scalp. 

The main cause of premature greying is probably intestinal dysbiosis based on Candida overgrowth in combination with its cousin pyroluria which causes severe deficiency of vitamin B6, zinc and various other vitamins and minerals. For details see Pyroluria. Together with vitamin C deficiency this also is an important cause of early aging skin and deteriorating blood vessels. 

There is much anecdotal evidence that increased blood circulation to the scalp can restore hair colour. This may be done by frequently keeping the head lower than the heart, such as with inversion equipment or slant boards, or by rubbing irritating substances into the scalp such as a solution of cayenne or some aromatic oils. Most difficult is restoring the colour of the beard as it is commonly greatly damaged by dental procedures, especially mercury and root canal treatments.

In my experience it is best to apply both, copper salicylate as well as sodium ascorbate. Depending on the vitality of the damaged hair bulbs, hair can recolour almost instantly, but generally it takes at least several weeks or even months, while some white hair may never recolour. I recommend to rub some copper salicylate solution into the hair/scalp once or twice a week but sodium ascorbate preferably daily, just rub some dissolved ascorbate into the scalp or beard. Initially it may come back as a light reddish colour which darkens over time, especially with additional application of PABA. 

How to use Vitamin C and MSM

Linus Pauling, two times Nobel prize winner, pioneered the daily use of 10 grams of vitamin C for the improvement and protection of health. He reportedly used himself between 10 and 18 grams/day for 35 years. However, even much smaller amounts can cause diarrhoea if taken all at once. Therefore use it well spread out during the day and night (in case you tend to wake up) but increase amounts only gradually to minimize the possibility of diarrhoea and cleansing reactions, cut back if problems arise.

It is best to use vitamin C and MSM together, such as up to 2 rounded teaspoons or 10 grams each of sodium ascorbate and MSM, and possibly 1 to 3 teaspoons of 50 to 70% DMSO rubbed on the skin at problem areas, such as for arthritis.

You may either frequently mix the powders with drink or food, or dissolve them in half to one litre of water, juice or herb tea, add some lemon juice and frequently sip during the day. You may also add magnesium chloride or magnesium oil, or borax, or other frequently taken nutrients such as other vitamins and minerals, but generally not oxidants such as MMS or Lugol's solution. If there are indications that you are too acidic and need additional alkalizers, then it is preferable to take sodium bicarbonate and/or potassium citrate separately before or between meals so that the gastric acid needed for digestions is not neutralised.

I would generally continue with 10 grams daily until the treated problem has been resolved, be it to get more energy, a chronic disease, liver problems, improving connective tissue, or just to clean out and strengthen the blood vessels. After about one year or with sufficient and sustained improvement you may try reducing to 5 grams daily and later even less. You may also cycle the dosage, go up and down in a slow wave form, remaining for several weeks each at the intended maximum and minimum levels which may go as low as 1 gram or zero with a good diet. Young and healthy individuals may remain healthy with several hundred milligrams of vitamin C available from a good diet.

Do not stop a high vitamin C intake suddenly as this can create a serious rebound deficiency, rather reduce high intakes gradually. In addition to a vitamin B complex, with chronic diseases use about 500 mg of niacinamide with breakfast and lunch because vitamin B3 is needed as the main coenzyme for energy-producing redox reactions. Niacinamide is also an effective anti-inflammatory agent.

If sodium ascorbate is not available look for buffered vitamin C. This may contain in addition to ascorbic acid ascorbates of calcium, magnesium, potassium and sodium, or more commonly and cheaper these minerals as carbonates. Buffered vitamin C is preferable with kidney disease, water retention and high blood pressure problems. Alternatively, you may use ascorbic acid and neutralise it in water by adding two parts to one part of sodium bicarbonate or mixed potassium, magnesium and calcium carbonates shortly before ingesting. You can drink it while it is still fizzing.

While vitamin C is known to be good as treatment for viral infections, recent research has shown that it is actually DHA that is the effective antimicrobial remedy, up to one thousand times stronger than the reduced form of vitamin C (16). These effects can be even stronger in the presence of copper ions. This may be the reason why blood copper levels are elevated during infections and inflammations, just waiting to team up with high levels of vitamin C.

With serious infections it may be helpful to oxidize vitamin C to DHA before ingestion for better absorption and a stronger effect. Dissolve a teaspoon of sodium ascorbate and 1 teaspoon of MSM in a large glass of water. Add a teaspoon of 3% or about 10 drops of 35% hydrogen peroxide, a teaspoon of glycerine and a tiny amount of a copper compound. This solution does not keep and needs to be made fresh every day. Take a sip of it frequently during the day. In this way you can get a stronger antimicrobial effect with less vitamin C (15).

In most EU countries, except the UK (see, sodium ascorbate powder in kilogram quantities is not available for human consumption, and even for veterinary use it is very expensive and difficult to obtain. These restrictions are most severe in Germany. Ascorbic acid is increasingly vilified in German internet articles. Ascorbic acid in kg amounts is only available as food preservative, not as a vitamin, and buyers may be checked to make sure that they do not intent to use it as a vitamin. I have no doubt that this attack originates from the German pharmaceutical industry which now tries to extend the German and EU ban on natural remedies world-wide with the Codex Alimentarius regulations and in coordination with similar draconian FDA regulations. 

Reactions and Side-Effects

I can confirm from my own experience that the recommended vitamin C/MSM works. However, with improving vitality the body also start to clean out accumulated waste products and toxins, and this can cause more or less severe reactions or side-effects in some individuals. These are commonly related to inflammatory effects caused by a revitalised immune system. The main effects that I have noticed so far are:

·        Microbial die-off or Herxheimer effect and autoimmune reactions

·        Initial worsening of inflammatory joint and skin problems

·        Cholesterol and oxidised fats from obstructed blood vessels may temporarily lodge in the skin

·        Mercury and possibly other toxic metals liberated from brain and tissues may temporarily increase in the blood

·        The body may become overacid due to increased inflammations

Most of these effects are beneficial in the long-term and can also happen with other methods of increasing the vitality of the body, and especially the activity of the immune system, but they need to be properly managed. Most of these problems arise either from overgrowth of Candida and other pathogenic microbes in intestines, blood, joints and tissues, and especially from poor liver functions which cause problems with the fat metabolism and prevent the removal of wastes and toxins through the liver.

The immune system requires a lot of vitamin C to overcome acute infections. Because vitamin C is usually in short supply, the immune system cannot do its job, and when acute infections subside, they become chronic instead, such as in the form of arthritis and autoimmune diseases. When the immune system now receives plenty of vitamin C it starts again attacking the invading microbes, and this can cause immune reactions with strong inflammations.

 A reverse effect is muscle pain during and after an infections, commonly experienced with influenza. This is due to vitamin C deficiency. If it persists it is called scurvy and includes feeling unwell, fatigue, loss of appetite, nausea, diarrhoea, fever, painful joints and muscles. There is then also a tendency of microbes moving into joints and causing arthritis or hiding in organs or glands and causing autoimmune diseases.

All this can be prevented by quickly increasing sodium ascorbate close to bowel tolerance levels during an acute infection. Dissolve several heaped teaspoons of it together with some MSM in a litre of herb tea (with freshly squeezed lemon or orange juice) and sip some of it every half hour while awake. Also take enough spaced-out sodium bicarbonate before meals to keep the urine alkaline, and finally try1/8 of a teaspoon of borax powder (may be dissolved in the vitamin C/MSM drink)  3-4 x per day (in all up to 2g/day) with food or drink. Borax protects the joints from getting arthritis, and supports the immune system in eliminating microbes and keeping the intestines free from pathogens. During this time you should not get any cleansing reactions from vitamin C. It also helps when removing pathogens from the intestines by having a psyllium drink with bicarbonate, garlic, ginger or other microbicides before breakfast.

When the infection is over reduce the level of vitamin C/MSM to a lower intake but then gradually try increasing again up to 10 grams of each. If a cleansing reaction develops reduce again, then increase again, always up and down like a wave gradually trying to push towards the 10 grams of vitamin C and MSM. If you keep up with a higher borax intake and additional vitamin D3 (see below) you can expect to get less reactions due to immune stimulation. Two grams of daily borax have cured lupus in 4 months, apparently without any strong immune reactions. If it is used in a high amount for a long period then it is advisable to leave borax off for one week each month to avoid it accumulating in the body, but generally it is preferable to alternate anti-microbials as detailed in The Ultimate Cleanse.

This may also be a successful strategy for psoriasis and other inflammatory skin conditions. Psoriasis tends to be intensified by high amounts of vitamin C. In one case someone who never had psoriasis before developed it after some time of taking 10 grams of sodium ascorbate. When this was reduced to 1-2 grams the psoriasis vanished again. I interpret this to mean that with psoriasis the skin is invaded by mycoplasmas, pleomorphic microbes or fungi, and when the activated immune system starts attacking then this causes the skin inflammation. 

An effective remedy against such skin inflammations seems to be vitamin D3 in high amounts. Initially try absorbing 5,000 IU several times daily under the tongue, and also mixing 5,000 IU or more with some extra virgin olive oil and rubbing it on the skin all over the body. When the inflammation has subsided continue with 5,000 IU orally and as skin rubs, except on days with adequate sun exposure on the skin.

Also helpful with skin inflammations are rubs with fresh green leaf or grass juice (this can also be made in a blender with water and strained, or try dissolved and strained wheat/barley grass powder). Also diluted glycerine may help - inflammatory skin may be caused by skin cells not maturing due to a lack of glycerine. This can also be rectified or improved by eating raw fats still containing lipase, such as raw butter, Shea butter, avocado, freshly extracted raw coconut fat, and raw egg yolk, or try an emulsion of extra virgin olive oil with water, lecithin and lipase, or adding lipase to oils or heated fats. Some of these may also be tried as skin rubs.

All conditions benefit from soaking in a bath with up to a cupful of sodium bicarbonate and about half this amount of magnesium chloride. Also beneficial is exposing inflamed skin to blue light, such as by covering it with blue cellophane and exposing it to strong light. With all infections and inflammatory conditions alkalize sufficiently to keep the urine alkaline. Finally, a main cause of inherited liver diseases appears to be Pyroluria which underlies many of our chronic diseases, especially in combination with Candida overgrowth. This calls for high amounts of zinc and P5P, which is the activated form of vitamin B6.


1) Science Blog 2007-09-10: How vitamin C stops the big 'C'

2) Gregg, David: DMSO and MSM - The Biochemical Oxygen Transport Pair; (different examples are from different pages of this website)

3) Pekker, Michael: Niacinamide (Vitamin B3) May Prevent Alzheimer’s Memory Loss;

4) Hoffer, Abram: Vitamin B-3 - Niacin and Its Amide;

5) Last, Walter: Cancer Therapy - A New Direction; 

6) Gregg, David: Cancer Health Notes;, also see the linked pages ..../cancer2.htm and ..../cancer3.htm

7) Solution to the Puzzle of Human Cardiovascular Disease: Its Primary Cause is Ascorbate deficiency, leading to the deposition of lipoprotein(a) and fibrinogen / fibrin in the vascular wall Matthias Rath and Linus Pauling Journal of Orthomolecular Medicine 1991, 6: 125-134

8) A Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of This Disease as a Cause for Human Mortality Matthias Rath M.D. and Linus Pauling Ph.D. Journal of Orthomolecular Medicine 1992, 7: 5-15

9) Last, Walter: Natural Therapy for Hemochromatosis;

10) Last, Walter: Antioxidants for Haemochromatosis. International Clinical Nutrition Review Volume 11, No.2, pages 71-74, 1991

11) Adams, R. and Murray. F.: Minerals: Kill or Cure? Larchmont Books, NY 1974.

12) Last, Walter: Copper Salicylate - A Potent Inflammation Fighter and Rejuvenator.

13) To buy copper salicylate see

14) ABC News in Science: Grey hair? Blame the bleach. 4 March 2009,  

15) Patent US8324269 - Stable compositions of dehydroascorbic acid;

16) Ayami Furuya et al: Antiviral effects of ascorbic and dehydroascorbic acids in vitro: (free pdf download)










Disclaimer: The aim of this web site is to provide information on using natural healing methods in the treatment of illness and health improvement. The author cannot accept any legal responsibility for any problem arising from experimenting with these methods. For any serious disease, or if you are unsure about a particular course of action, seek the help of a competent health professional. I do not recommend using DMSO or high doses of vitamins for treating humans in countries where this is illegal.